[Comparison of the effects of adcortyl ointment [triamcinolone in orabase] and triamcinolone mouthwash on oral lichen planus]

Oral lichen planus [OLP] is a common chronic immunologic mucocutaneous disorder with various types. Erosive and bullous types are painful and require treatment. In treatment of Lichen planus, various topical and systemic corticosteroids are used. The purpose of this study was to compare the effects of Adcortyl [Triamcinolone in orabase] and triamciniolone mouthwash in the treatment of oral lichen planus. This experimental study was conducted on 60 patients in two equal groups affected by erosive or atrophic lichen planus. Type and size of the lesions were gathered by mm[2] and the severity of pain by VAS. The first group was treated with%0.2 triamciniolone mouthwash and the second group by Adcortyl [triamcinolone in orabase]. The patients were evaluated after one month. The size of lesions and severity of pain were recorded and compared before and after treatment. The data were analyzed using T- test. This study showed a significant reduction in the size and severity of pain of the lesions after treatment using%0.2 triamcinolone mouthwash and Adcortyl in each group, but the difference between the two groups was not significant. Adcortyl and triamcinolone mouthwash were useful in healing and reduction of pain from lesion. The properties of triamcinolone mouth wash including internal production of triamcinolone ampoule, easy formulation and availability, convenient use, contact with the distal surfaces of the oral cavity, and preventing new eruptions introduces it as a useful drug to control the symptoms of OLP

[Evaluation of the effects of chlorhexidine 0.12% mouthwash on mouth pathogen streptococcus and normal microflora]

Mouthwashes like brush and dental floss, can cause reduction in dental plaque and gingivitis. An optimal mouthwash should have antimicrobial properties, low drug resistance, and cause no decrease in normal microflora of the mouth. The purpose of this study was the evaluation of the effects of chlorhexidine 0.12% mouthwash on pathogen streptococcus and normal microflora of the mouth. In this experimental study, based on selected inclusion criteria, 28 subjects, were selected and asked to use 0.12% chlorhexidine mouthwash for 2 weeks, according to the manufacturer instruction. Before and after rinsing with the mouthwash, subjects were requested to wash their mouth with physiologic serum. After washing, 1cc of saliva of each individual was collected in sterile tube and immediately sent to microbiology laboratory. This process was repeated 2 weeks after using mouthwash. The number of pathogen streptococcus and normal microflora colonies of the mouth before and after using chlorhexidine were recorded. For analyzing the data, T and Chi Square Test were used.: Chlorhexidine mouthwash [0.12%] significantly decreased numbers of the pathogen streptococcus and mouth normal microflora [p <0/05] This study showed that, 0.12% chlorhexidine mouthwash, can destroy not only the mouth pathogen streptococci, but also the normal microflora of the mouth. The latter should be considered as its side effect